The monitoring of selected lichen metabolites on the angiogenesis, tumor cell proliferation and pathogenic yeast growth
Basic information
Slovak title:
Sledovanie vplyvu metabolitov vybraných lišajníkov na angiogenézu, proliferáciu nádorových buniek a rast patogénnych kvasiniek
Registration No.:
1/0071/21
Source:
Scientific grant agency (Ministry of education, science, research and sport of the Slovak Republic)
Implementation time:
2021 - 2023
Principal (UVMP):
Bačkorová Miriam, RNDr., PhD. (2021: % | 2022: % | 2023: %)
Principal workplace:
Department of Pharmaceutical Technology, Pharmacognozy and Botany
Principal workplace:
Department of Pharmaceutical Technology, Pharmacognozy and Botany
Contributors:
Čonková Eva, doc. MVDr., PhD. (2021: % | 2022: % | 2023: %)
Eftimová Jarmila, doc. Ing., CSc. (2021: % | 2022: % | 2023: %)
Kurhajec Slavomír, PharmDr., Ph.D. (2021: % | 2022: % | 2023: %)
Šmejkal Karel, prof. PharmDr., Ph.D. (2021: % | 2022: % | 2023: %)
Ungvarská Maľučká Lucia, RNDr., PhD. (2021: % | 2022: % | 2023: %)
Váczi Peter, doc. MVDr., PhD. (2021: % | 2022: % | 2023: %)
Uhrinová Anna, RNDr., PhD. (2021: % | 2022: % | 2023: %)
Field of study:
-
Financial indicators
NON-CAPITAL FUNDING in €
CAPITAL FUNDING in €
Allocated
Spent
Allocated
Spent
Allocated / Spent
Allocated / Spent
2021
0
0
0
0
0 / 0
0 / 0
2022
0
0
0
0
0 / 0
0 / 0
2023
0
0
0
0
0 / 0
0 / 0
Spolu
0
0
0
0
0 / 0
0 / 0
Anotation
Hlavnou témou predkladaného projektu je zistenie účinkov extraktov z rôznych druhov lišajníkov a ich zložiek na angiogenézu, proliferáciu nádorových buniek a rast patogénnych kvasiniek rodov Candida a Malassezia. Angiogenéza sa bude študovať metódou in ovo a ex ovo na modeli chorioalantoickej membrány vtáčieho embrya (CAM model). V našom prípade bude vtáčim emryom kura domáca a prepelica japonská. Antiproliferatívny účinok bude testovaný v in vitro podmienkach na bunkových nádorových líniách. Antimykotická aktivita bude stanovená na referenčných kmeňoch a klinických izolátoch Candida albicans a Malassezia pachydermatis.
The main topic of this project is to find out the effects of extracts from various lichen species and their components on angiogenesis, tumor cell proliferation and the growth of pathogenic yeasts of Candida and Malassezia. Angiogenesis will be studied by the in ovo method in the chicken and Japanse quail embryo chorioallantoic membrane (CAM model). The antiproliferative effect will be tested in vitro on the tumor cell lines. Antimycotic activity will be determined by reference and isolate species of Candida albicans and Malassezia pachydermatis.
Publication outputs