The influence of intestinal mucosal immunity and the intestinal microbiome on the central nervous system in neurodegenerative disease - an animal model
Basic information
Slovak title:
Vplyv slizničnej imunity čreva a mikrobiómu čreva na centrálny nervový systém pri neurodegeneratívnom ochorení- animálny model
Registration No.:
1/0181/25
Source:
Scientific grant agency (Ministry of education, science, research and sport of the Slovak Republic)
Implementation time:
2025 - 2028
Principal (UVMP):
Levkut Martin, doc. MVDr., PhD. (2025: 100% | 2026: 100% | 2027: 100% | 2028: 100%)
Principal workplace:
Department of Morphological Disciplines
Principal workplace:
Department of Morphological Disciplines
Contributors:
Ševčíková Zuzana, prof. MVDr., PhD. (2025: 40% | 2026: 40% | 2027: 40% | 2028: 40%)
Šulla Igor, MVDr., PhD. (2025: 75% | 2026: 75% | 2027: 75% | 2028: 75%)
Šimaiová Veronika, MVDr., PhD. (2025: 50% | 2026: 50% | 2027: 50% | 2028: 50%)
Szabóová Renáta, doc. MVDr., PhD. (2025: 30% | 2026: 30% | 2027: 30% | 2028: 30%)
Herich Róbert, prof. MVDr., PhD. (2025: 50% | 2026: 50% | 2027: 50% | 2028: 50%)
Field of study:
200 - Veterinary Sciences
Financial indicators
NON-CAPITAL FUNDING in €
CAPITAL FUNDING in €
Allocated
Spent
Allocated
Spent
Allocated / Spent
Allocated / Spent
2025
15626
0
0
0
15626 / 0
0 / 0
2026
0
0
0
0
0 / 0
0 / 0
2027
0
0
0
0
0 / 0
0 / 0
2028
0
0
0
0
0 / 0
0 / 0
Spolu
15626
0
0
0
15626 / 0
0 / 0
Anotation
Črevná mikroflóra sa objavuje ako kľúčový regulátor mnohých chorobných stavov a jej dysregulácia sa podieľa na patogenéze niekoľkých gastrointestinálnych a extraintestinálnych porúch. Nedávno boli zmeny črevného mikrobiómu spojené s neurodegeneráciou Alzheimerovho typu (ACH) prostredníctvom čoraz viac definovanej osy „mozog- črevná mikrobiota“. To otvára alternatívu pre nové terapeutické možnosti tejto choroby založené na mikrobiote a imunite črevného systému. Výsledky viacerých štúdii ukazujú, že probiotické baktérie môžu modulovať osadenie črevnej mikroflóry benefičnými mikroorganizmami, regulovať stav dysbiózy čreva a následne ovplyvňovať os črevo-mozog.
The gut microbiota is emerging as a key regulator of many disease states, and its dysregulation is implicated in the pathogenesis of several gastrointestinal and extraintestinal disorders. Recently, alterations in the gut microbiota have been linked to Alzheimer\\\'s disease (AD) neurodegeneration through an increasingly defined \\\"brain-gut microbiota\\\" axis. This opens up the possibility of novel therapeutic options for this disease based on the gut microbiota and immunity. Several studies have shown that probiotic bacteria can modulate the colonization of the gut microbiota by beneficial microorganisms, regulate the state of gut dysbiosis, and consequently influence the gut-brain axis.
Publication outputs